New Research Shows Hyperactive Neurons May Trigger Alzheimer’s

Hyperactive neurons may be culprit in Alzheimer’s

Amyloid plaques in blue are surrounded by damaged neuronal branches.

New research from Yale University shows that an increase in neuronal activity can spur the creation of plaques and toxic amyloid beta peptides, which are believed to trigger Alzheimer’s disease.

A long-term reduction in neuronal activity reduces amyloid plaques associated with Alzheimer’s disease, Yale University researchers have found. The study, using mouse models of Alzheimer’s, found the opposite is also true — triggering an increase in neuronal activity spurs creation of plaques and toxic amyloid beta peptides believed to trigger the disease.

Neuroscientists Jaime Grutzendler and Peng Yuan used a new technology called chemogenetics to alternately inhibit or excite neuronal signaling in mice with Alzheimer’s. The goal was to test the theory that hyperactivity in neurons might contribute to the onset of Alzheimer’s. Such an increase in neuronal activity might trigger the production of excess amounts of amyloid beta peptides, which in turn may be toxic to brain cells and cause the symptoms of dementia, Grutzendler said.

On the other hand, suppressing this hyperactivity could be a novel way of halting the progression of the disease, he noted.

Publication: Peng Yuan and Jaime Grutzendler, “Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity,” The Journal of Neuroscience, 13 January 2016, 36(2): 632-641; doi: 10.1523/JNEUROSCI.2531-15.2016

Source: Bill Hathaway, Yale University


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